Pathological effect of hydrargyria on murine systemic physiology. Ayacucho 2020

Abstract

The present research work has to evaluate the pathophysiological effect of hydrargyria in systemic structures of murines, which was carried out in the laboratory of Physiology and Natural Sciences of the Faculty of Biological Sciences.

Twelve albino Mus musculus mice of the Balb/c variety were used, where treatments were carried out in three experimental groups and one control. It is worth mentioning that 12 male and female mice were used, and the average age was 50 days. Each experimental group consisted of 3 mice, to which 1 ml of mercuric bichloride was applied 1mg for Group I, 2mg for Group II and 3mg for Group III by oral route. The readings of the experimental groups were made at 3, 6 and 12 days, where the creatinine concentration for group I was 0.3 mg/dl, group II 0.7 mg/dl and group III 0.6 mg/dl. The second reading was carried out 6 days later with the following result: group I 0.4 mg/dl, group II 0.8 mg/dl and group III 0.9 mg/dl. The third reading was performed on day 9: group I increased to 0.6 mg/dl, group II to 0.9 mg/dl, and group III to 1.0 mg/dl. In other words, as time goes by, creatinine levels increase, which means that mercury accumulates in the organs, damaging them to the point of generating complications. After 10 days of evaluating the symptoms, the corresponding autopsies were performed with 66.67% kidney damage, 22.22% pulmonary affections and 11.11% internal bleeding. Statistically there was no significant difference.